The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice

@article{Haruna2017TheIE,
  title={The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice},
  author={Takayo Haruna and Masahiko Soga and Yasuhide Morioka and Kinichi Imura and Yoko Furue and Mina Yamamoto and Junpei Hayakawa and Masashi Deguchi and Akinori Arimura and Kiyoshi Yasui},
  journal={Pharmacology},
  year={2017},
  volume={99},
  pages={259 - 267}
}
We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The oral administration of S-777469 significantly suppressed DNFB-induced ear swelling in a dose-dependent manner. In addition, S-777469 significantly alleviated mite antigen-induced… 

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