The Inhibitory Co-Receptor, PECAM-1 Provides a Protective Effect in Suppression of Collagen-Induced Arthritis

@article{Wong2005TheIC,
  title={The Inhibitory Co-Receptor, PECAM-1 Provides a Protective Effect in Suppression of Collagen-Induced Arthritis},
  author={M Wong and John D Hayball and P Mark Hogarth and Denise E. Jackson},
  journal={Journal of Clinical Immunology},
  year={2005},
  volume={25},
  pages={19-28}
}
Studies of PECAM-1−/− mice have identified that PECAM-1 functions as an inhibitory co-receptor to modulate immunological responsiveness. In this study, we describe the in vivo consequences of PECAM-1 deficiency in mouse models of collagen-induced arthritis (CIA) and K/BxN passive transfer model that resembles many of the features of human rheumatoid arthritis. Immunization of PECAM-1−/− C57BL/6 (H-2 b ) mice with chicken collagen type II induced CIA with an incidence of 82% by day 49, while 33… CONTINUE READING