The Inhibition of the N-Methyl-d-Aspartate Receptor Channel by Local Anesthetics in Mouse CA1 Pyramidal Neurons

  title={The Inhibition of the N-Methyl-d-Aspartate Receptor Channel by Local Anesthetics in Mouse CA1 Pyramidal Neurons},
  author={Nobuyasu Nishizawa and Tetsuya Shirasaki and Shin‐ichi Nakao and Hiroko Matsuda and Koh Shingu},
  journal={Anesthesia \& Analgesia},
Although the effects of local anesthetics on sodium channels and various other channels and receptors have been intensively investigated, there is little information available about their effects on N-methyl-d-aspartate (NMDA) receptors. We examined the effects of four local anesthetics (procaine, tetracaine, bupivacaine, and lidocaine) on NMDA-induced currents by using a whole-cell patch-clamp technique in dissociated mouse hippocampal pyramidal neurons. Procaine and tetracaine produced a… 

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