The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity

  title={The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity},
  author={Wenzhang Wang and Luwen Wang and Junjie Lu and Sandra Siedlak and Hisashi Fujioka and Jingjing Liang and Sirui Jiang and Xiaopin Ma and Zhen Jiang and Edroaldo Lummertz da Rocha and Max Sheng and Heewon Choi and Paul H. Lerou and Hu Li and Xinglong Wang},
  booktitle={Nature Medicine},
Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological feature of degenerating neurons in various neurodegenerative diseases. However, the molecular mechanisms by which TDP-43 contributes to ALS pathophysiology remain elusive. Here we have found that TDP-43 accumulates in the mitochondria of neurons in subjects with… CONTINUE READING


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