The Inheritance of Tourette Disorder: A review.

@article{Pauls2014TheIO,
  title={The Inheritance of Tourette Disorder: A review.},
  author={David L. Pauls and Thomas V. Fernandez and Carol A. Mathews and Matthew W. State and Jeremiah M. Scharf},
  journal={Journal of obsessive-compulsive and related disorders},
  year={2014},
  volume={3 4},
  pages={
          380-385
        }
}
The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery
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These complementary large-scale efforts are joining forces to uncover the full range of genetic variation and environmental risk factors for TS, holding great promise for identifying definitive TS susceptibility genes and shedding light into the complex pathophysiology of this disorder.
Progress in Genetic Studies of Tourette’s Syndrome
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The main purpose for this review will be to summarize the new genetic discoveries of TS based on novel genetic methods and strategies, such as genome-wide association studies (GWASs), whole exome sequencing (WES) and whole genome sequencing(WGS) and compared with other major psychiatric disorders to understand the current status of TS genetics and its relationship with other psychiatric disorders.
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The findings that are emerging from genetic studies will allow researchers to piece together the underlying components of the disease in the hopes that a deeper understanding of Tourette syndrome can lead to improved treatments for those affected by it.
Genetic Studies of Tic Disorders and Tourette Syndrome.
TLDR
The main purpose for this review will be to summarize the new genetic discoveries of TS based on novel genetic methods and strategies, such as genome-wide association studies (GWASs), whole exome sequencing (WES), and whole genome sequencing (wGS) and compare them with other major psychiatric disorders in order to understand the current status of TS genetics.
Tics and Tourette: a clinical, pathophysiological and etiological review
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  • Medicine, Biology
    Current opinion in pediatrics
  • 2017
TLDR
Investigation of blood cytokines, blood mRNA and brain mRNA expression support the role of a persistent immune activation, and there are similarities with the immune literature of autistic spectrum disorder.
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
TLDR
It is concluded that reduced PNKD long isoform levels are detected in all affected individuals and evidence for a mechanism whereby this might contribute to the TD phenotype is provided.
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research
TLDR
It is proposed that some general epigenetic mechanisms seen in other neuropsychiatric disorders may also play a role in the pathogenesis of Tourette Syndrome.
Tics and Tourette syndrome
  • R. Dale
  • Psychology, Medicine
    Journal of the Neurological Sciences
  • 2021
TLDR
The clinical features and pathophysiology of Tourette syndrome are reviewed, and a pragmatic management approach is discussed.
Parity in Tourette Syndrome: Reproducible Risk Factors for an Underrecognized Neurodevelopmental Disorder.
  • J. Scharf
  • Medicine, Psychology
    The Journal of pediatrics
  • 2016
Copy Number Variation in Neuropsychiatric Disorders
TLDR
This thesis describes a CNV study of 26 large, multigenerational families with a high incidence of BP from two population isolates, using both microarray and whole-genome sequencing data, and provides evidence for an increased female CNV burden for BP.
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The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission.
TLDR
Analysis of segregation analyses in 30 nuclear families provides strong support for the hypothesis that obsessive-compulsive disorder is etiologically related to Tourette's syndrome and chronic tics in these families, and that Tourette’s syndrome is inherited as a highly penetrant, sex-influenced, autosomal dominant trait.
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