The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank

@inproceedings{Guerrera2016TheIO,
  title={The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank},
  author={Francesco Guerrera and Fabrizio Tabb{\'o} and Luca Bessone and Francesca Maletta and Marcello Gaudiano and Elisabetta Ercole and Laura Annaratone and Maria Todaro and Monica Boita and Pier Luigi Filosso and Paolo Solidoro and Luisa Delsedime and Alberto Oliaro and Anna Sapino and Enrico Ruffini and Giorgio Inghirami and Rossella Rota},
  booktitle={PloS one},
  year={2016}
}
INTRODUCTION Bio-repositories are invaluable resources to implement translational cancer research and clinical programs. They represent one of the most powerful tools for biomolecular studies of clinically annotated cohorts, but high quality samples are required to generate reliable molecular readouts and functional studies. The objective of our study was to define the impact of cancer tissue ischemia time on RNA and DNA quality, and for the generation of Patient-Derived Xenografts (PDXs… CONTINUE READING