The Influence of T Cell Development on Pathogen Specificity and Autoreactivity
@article{Komrlj2012TheIO, title={The Influence of T Cell Development on Pathogen Specificity and Autoreactivity}, author={Andrej Ko{\vs}mrlj and Mehran Kardar and Arup K. Chakraborty}, journal={Journal of Statistical Physics}, year={2012}, volume={149}, pages={203-219} }
T cells orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors on their surface to short peptides derived from foreign proteins bound to protein products of the major histocompatibility (MHC) gene products, which are displayed on the surface of antigen presenting cells. T cells can also interact with peptide-MHC complexes, where the peptide is derived from host (self) proteins. A diverse repertoire of relatively self…
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References
SHOWING 1-10 OF 82 REFERENCES
How the thymus designs antigen-specific and self-tolerant T cell receptor sequences
- Biology, MedicineProceedings of the National Academy of Sciences
- 2008
A dominant role for negative selection in mediating antigen specificity of mature T cells and a molecular mechanism for TCR recognition of antigen are described.
Thymic selection of T-cell receptors as an extreme value problem.
- BiologyPhysical review letters
- 2009
Thymic selection processes are mapped to an extreme value problem and an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions) are provided.
A quantitative theory of affinity-driven T cell repertoire selection.
- BiologyJournal of theoretical biology
- 1999
The role of the MHC and peptide contribution to TCR binding is analysed, and it is found that their relative, rather than absolute value, is important in shaping the mature repertoire.
The why and how of thymocyte negative selection.
- BiologyCurrent opinion in immunology
- 2006
Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1999
The results show that the affinity model of T cell selection can quantitatively explain both self MHC restriction and high alloreactivity.
The effects of thymic selection on the range of T cell cross‐reactivity
- BiologyEuropean journal of immunology
- 2005
Based on the results of a computational model of thymic selection, a mechanism that produces the observed wide range of T cell cross‐reactivity is proposed that is correlated with its affinity for self peptides.
A constant affinity threshold for T cell tolerance
- BiologyThe Journal of experimental medicine
- 2007
Using three transgenic mouse strains expressing distinct class I MHC–restricted T cell receptors, the affinity that defines the threshold for negative selection appears to be a constant for cytotoxic T lymphocytes.
Antigen-presenting function of the macrophage.
- BiologyAnnual review of immunology
- 1984
The available information leads one to conclude that APC deficient in their capacity to internalize and process proteins will not be able to present them, and the macrophage is the candidate as the major APC involved in the recruitment and enlargement of clones T cells.
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
- BiologyNature
- 2006
It is shown that, at the selection threshold, a small increase in ligand affinity for the T-cell antigen receptor leads to a marked change in the activation and subcellular localization of Ras and mitogen-activated protein kinase (MAPK) signalling intermediates and the induction of negative selection.