The Influence of Subthalamic Nucleus Lesions on Sign-Tracking to Stimuli Paired with Food and Drug Rewards: Facilitation of Incentive Salience Attribution?

@article{Uslaner2008TheIO,
  title={The Influence of Subthalamic Nucleus Lesions on Sign-Tracking to Stimuli Paired with Food and Drug Rewards: Facilitation of Incentive Salience Attribution?},
  author={Jason M. Uslaner and James M Dell'Orco and Alex Pevzner and Terry E. Robinson},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={2352-2361}
}
It is well known that the subthalamic nucleus (STN) plays an important role in regulating motor function, but recent studies suggest the STN is also involved in regulating motivated behavior. For example, bilateral lesions of the STN increase motivation for both food and cocaine as assessed by ‘breakpoint’ on a progressive ratio schedule. However, the psychological mechanism(s) by which STN lesions increase motivation for rewards is unknown. We hypothesized that STN lesions might influence one… CONTINUE READING

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