The Influence of Retinoic Acid and Retinoic Acid Derivatives on β2 Integrins and L-Selectin Expression in HL-60 Cells In Vitro

@article{Sjgren2000TheIO,
  title={The Influence of Retinoic Acid and Retinoic Acid Derivatives on β2 Integrins and L-Selectin Expression in HL-60 Cells In Vitro},
  author={Florence Sj{\"o}gren and Olle Stendahl and Olof C. Ljunghusen},
  journal={Inflammation},
  year={2000},
  volume={24},
  pages={21-32}
}
A decreased expression of the β2-integrin CD11b molecules on peripheral neutrophils from patients with pustular psoriasis occurred during treatment with retinoid compounds. Since this effect could not be mimicked in vitro with isolated peripheral neutrophils, the effect of retinoid compounds on cell differentiation was investigated. The promyelocytic cell line, HL60, was used to study what effect different retinoid compounds had on the cell surface expression of CD11b and L-selectin (CD62L… CONTINUE READING

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