The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux—A Prospective Longitudinal Interventional Study

@inproceedings{Castellani2017TheIO,
  title={The Influence of Proton Pump Inhibitors on the Fecal Microbiome of Infants with Gastroesophageal Reflux—A Prospective Longitudinal Interventional Study},
  author={Christoph Castellani and Georg Singer and Karl Kashofer and Andrea Huber-Zeyringer and Christina Flucher and Margarita Kaiser and Holger Till},
  booktitle={Front. Cell. Infect. Microbiol.},
  year={2017}
}
Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). In contrast to adults the microbiome of infants develops from sterility at birth toward an adult-like profile in the first years of life. The effect of PPIs on this developing microbiome has never been studied. The aim of the present study was to determine the effect of oral PPIs on the fecal microbiome in infants with… CONTINUE READING
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