The Influence of Pharmaceutical Compounds on Male Fertility *

@article{Neumann1976TheIO,
  title={The Influence of Pharmaceutical Compounds on Male Fertility *},
  author={Friedmund Neumann and F A Diallo and S. H. Hasan and B. Schenck and I Traore},
  journal={Andrologia},
  year={1976},
  volume={8}
}
1. Steroid hormones can affect spermatogenesis and thereby fertility directly and/or indirectly. All antigonadotropically active steroids inhibit spermatogenesis via inhibition of gonadotropin secretion, mainly that of H. Androgens and steroids occurring in the biosynthetic chain of testosterone synthesis have a direct promoting effect on spermatogenesis if applied in high doses. It has not been possible as yet to make clinical use of this positive effect since it is obviously not possible to… Expand
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Effects of drugs and chemicals on spermatogenesis.
  • F. Neumann
  • Chemistry, Medicine
  • Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
  • 1984
TLDR
Several points of interference have to be considered: inhibition of gonadotrophin secretion, inhibition of enzymes involved in androgen biosynthesis, direct effects on the germinal epithelium or on Sertoli cell function, competitive inhibition of hormone action, damage of the blood-testes barrier and other mechanisms. Expand
Antiandrogens: basic concepts and clinical trials.
TLDR
Experiments have demonstrated that spermatogenesis can be maintained in hypophysectomized animals by means of adequate replacement with androgens alone or with androgen precursors, although the doses required are extremely high. Expand
The Effects of Drugs on Sperm
TLDR
Drug treatment of idiopathic oligozoospermia is disappointing, though gonadotrophins or their releasing hormone are useful in treating gonadOTrophin deficiency and there is still no suitable ‘male pill’ as far as contraception is concerned. Expand
Non-steroidal interference with male fertility
  • B. Vickery
  • Biology, Medicine
  • Advances in contraception : the official journal of the Society for the Advancement of Contraception
  • 1986
TLDR
This review demonstrates that contrary to popular belief the achievement of a male contraceptive has been a major scientific goal for the past 35 years; most of the theoretically possible sites of action have been explored. Expand
Effects of cyproterone acetate with combination of testosterone enanthate on seminal characteristics, androgenicity and clinical chemistry in langur monkey.
TLDR
The results indicate that the combination regimen seems to affect the fertility in two ways, i.e. by inhibiting spermatogenesis in the testis and maturation process in the epididymis without altering the androgenicity. Expand
The human testes: Estrogen and ageing outlooks
Abstract This survey highlights some of the fine structures and functions associated with estrogen in the human testes, ageing and contraception. Clarifications obtained with knockout mice models as… Expand
Evaluation of STS-557 as an oral contraceptive in male rat.
TLDR
Evaluation in castrated rat model revealed that STS-557 is a weak anti-androgen; its inhibitory effect on Leydig cell function is a contraindication for its use as a male oral contraceptive. Expand
Effects of cyproterone acetate on the reproductive tract and pituitary‐gonadal axis of the golden hamster
TLDR
The absence of an inhibitory action of CA on the testis could be explained through an increase in LH stimulation, thus suggesting that in the golden hamster CA is devoid of progestagenic partial effects. Expand
Endogenous antispermatogenic agents: prospects for male contraception.
TLDR
The most promising solution for the development of an antispermatogenic male contraceptive is the interference with the adenohypophyseal-gonadal axis via the subcutaneous sustained release of steroid formulations containing either androgens-danazol, androgen-progestin, or androgen -estrogen formulations. Expand
Drug-induced histological changes in rat seminiferous tubular epithelium.
  • A. Zschauer, C. Hodel
  • Chemistry, Medicine
  • Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
  • 1980
It is proposed to divide antispermatogenic compounds into four main groups on the basis of the morphological changes which they cause: a) Radiomimetic substances (e.g., Busulfan). These have a direct… Expand
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