The Influence of Pharmaceutical Compounds on Male Fertility *

@article{Neumann1976TheIO,
  title={The Influence of Pharmaceutical Compounds on Male Fertility *},
  author={Friedmund Neumann and F A Diallo and S. H. Hasan and B. Schenck and I Traore},
  journal={Andrologia},
  year={1976},
  volume={8}
}
1. Steroid hormones can affect spermatogenesis and thereby fertility directly and/or indirectly. All antigonadotropically active steroids inhibit spermatogenesis via inhibition of gonadotropin secretion, mainly that of H. Androgens and steroids occurring in the biosynthetic chain of testosterone synthesis have a direct promoting effect on spermatogenesis if applied in high doses. It has not been possible as yet to make clinical use of this positive effect since it is obviously not possible to… Expand
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2
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References

SHOWING 1-10 OF 152 REFERENCES
The effect of androgen on spermatogenesis.
introduction1 The inhibiting effects of the male sex hormone on testis weight and spermatogenesis in the rat have been reported by numerous workers using wide ranges of doses of androgens in variousExpand
EFFECTS OF PROGESTATIONAL COMPOUNDS ON THE REPRODUCTIVE PROCESSES OF THE HUMAN MALE
TLDR
The following represents a preliminary report on the effects of these steroids upon the male reproductive system during the treatment and the immediate posttreatment periods. Expand
Chemical control of spermatogenesis.
TLDR
Both naturally occurring and synthetic sex steroids have been shown to be effective inhibitors of gondotropin secretion and Estrogenic and the 19-nor progestins are highly effective. Expand
THE ACTION OF VARIOUS STEROID HORMONES ON THE TESTIS
TLDR
It has now definitely been proven that even pure crystalline sex hormones are capable of producing gonad atrophy. Expand
Effects of progesterone and synthetic progestins on the reproductive physiology of normal men.
TLDR
Men who received 50 mg progesterone/day testes were somewhat impaired but not to the extent produced by a shorter duration of medication with the synthetic progestins, and Mechanisms of action were discussed. Expand
Effect of Dosage on the Morphogenetic Actions of Testosterone
TLDR
It is concluded that many of the apparent contradictions concerning the morphogenetic actions of androgens—and perhaps also of other steroid hormones—are due to the fact that depending on the dose given, these compounds may exert diametrically opposite actions on certain organs. Expand
Control of spermatogenesis in men by combined administration of progestin and androgen
Abstract In six different patient groups with mild urological disorders, a combination therapy of progestin and testosterone was carried out and the effects of this treatment on spermatogenesis andExpand
EFFECTS OF EXOGENOUS ANDROGEN AND GONADOTROPINS ON THE TESTES AND HYPOPHYSIAL FOLLICLE-STIMULATING HORMONE CONTENT OF THE IMMATURE MALE RAT.
TLDR
While LH prevented much of the reduction in FSH potency seen in males treated with 50 μg of TP alone, it did not alter effects produced by higher doses. Expand
Prevention by Certain Steroids of Testicular Atrophy Usually Elicited by Small Doses of Testosterone.∗
TLDR
Experiments on post-pubertal albino rats indicate that androstenediol and pregnenolone prevent the testis atrophy otherwise produced by small doses of testosterone, and suggest that therapeutic doses ofosterone may be given in cases of eunuchoidism without the danger of producing testisatrophy. Expand
Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man.
TLDR
Following chemotherapy, testicular damage was restricted to the germinal tissue, and this in turn was associated with a selective increase in FSH, since FSH levels are only half as high as those reported for castrate men, other testicular factors may modify FSH secretion. Expand
...
1
2
3
4
5
...