The Influence of Moderate Hypercapnia on Neural Activity in the Anesthetized Nonhuman Primate

@article{Zappe2008TheIO,
  title={The Influence of Moderate Hypercapnia on Neural Activity in the Anesthetized Nonhuman Primate},
  author={A. C. Zappe and K{\^a}mil Uludağ and Axel Oeltermann and K{\^a}mil Uğurbil and N. K. Logothetis},
  journal={Cerebral Cortex (New York, NY)},
  year={2008},
  volume={18},
  pages={2666 - 2673}
}
Hypercapnia is often used as vasodilatory challenge in clinical applications and basic research. In functional magnetic resonance imaging (fMRI), elevated CO(2) is applied to derive stimulus-induced changes in the cerebral rate of oxygen consumption (CMRO(2)) by measuring cerebral blood flow and blood-oxygenation-level-dependent (BOLD) signal. Such methods, however, assume that hypercapnia has no direct effect on CMRO(2). In this study, we used combined intracortical recordings and fMRI in the… CONTINUE READING
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