The Influence of Intestinal Mucus Components on the Diffusion of Drugs

  title={The Influence of Intestinal Mucus Components on the Diffusion of Drugs},
  author={Agneta Wikman Larhed and Per Artursson and Erik Bj{\"o}rk},
  journal={Pharmaceutical Research},
Purpose. Mucus, a potential diffusional barrier to drug absorption, is a complex mixture of mucin and other components. The objective of this study was to investigate the composition of native pig intestinal mucus (PIM) and the influence of identified mucus components on drug diffusion. Methods. The mucus components were separated by CsCl-density gradient centrifugation and further analyzed. The self-diffusion coefficients of mannitol, metoprolol, propranolol, hydrocortisone, and testosterone… CONTINUE READING


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