The Influence of Immunosuppressive Agents on the Risk of De Novo Donor-Specific HLA Antibody Production in Solid Organ Transplant Recipients

@inproceedings{OLeary2016TheIO,
  title={The Influence of Immunosuppressive Agents on the Risk of De Novo Donor-Specific HLA Antibody Production in Solid Organ Transplant Recipients},
  author={Jacqueline G. O'Leary and Millie D Samaniego and Marta Crespo Barrio and Luciano Potena and Adriana Zeevi and Arjang Djamali and Emanuele Cozzi},
  booktitle={Transplantation},
  year={2016}
}
Production of de novo donor-specific antibodies (dnDSA) is a major risk factor for acute and chronic antibody-mediated rejection and graft loss after all solid organ transplantation. In this article, we review the data available on the risk of individual immunosuppressive agents and their ability to prevent dnDSA production. Induction therapy with rabbit antithymocyte globulin may achieve a short-term decrease in dnDSA production in moderately sensitized patients. Rituximab induction may be… CONTINUE READING
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