The Influence of Concentration/Meditation on Autonomic Nervous System Activity and the Innate Immune Response: A Case Study

@article{Kox2012TheIO,
  title={The Influence of Concentration/Meditation on Autonomic Nervous System Activity and the Innate Immune Response: A Case Study},
  author={Matthijs Kox and Monique Stoffels and Sanne P. Smeekens and Nens van Alfen and Marc E R Gomes and Thijs M. H. Eijsvogels and Maria T. E. Hopman and Johannes G. van der Hoeven and Mihai G. Netea and Peter Pickkers},
  journal={Psychosomatic Medicine},
  year={2012},
  volume={74},
  pages={489–494}
}
Objective In this case study, we describe the effects of a particular individual’s concentration/meditation technique on autonomic nervous system activity and the innate immune response. The study participant holds several world records with regard to tolerating extreme cold and claims that he can influence his autonomic nervous system and thereby his innate immune response. Methods The individual’s ex vivo cytokine response (stimulation of peripheral blood mononuclear cells with… 

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References

SHOWING 1-10 OF 30 REFERENCES

Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans.

  • F. SaykA. Vietheer C. Dodt
  • Medicine, Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2008
It is concluded that endotoxin challenge in healthy humans has rapid suppressive effects on postsynaptic sympathetic nerve activity to the muscle vascular bed and alters baroreflex function which may contribute to the untoward cardiovascular effects of sepsis.

Endotoxemia-induced inflammation and the effect on the human brain

Short-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy, but primarily results in an inflammation-mediated increase in cortisol and alertness.

Changes in cytokine production in healthy subjects practicing Guolin Qigong : a pilot study

  • B. Jones
  • Medicine, Biology
    BMC complementary and alternative medicine
  • 2001
Preliminary studies in healthy subjects have indicated that blood levels of the stress-related hormone cortisol may be lowered by short-term practice of Qigong and that there are concomitant changes in numbers of cytokine-secreting cells.

Low-dose steroid alters in vivo endotoxin-induced systemic inflammation but does not influence autonomic dysfunction

Severe injury and infection are associated with autonomic dysfunction. Diminished heart rate variability (HRV) is also observed as a component of autonomic dysfunction and is induced by endotoxin

Acute Stress Elicited by Bungee Jumping Suppresses Human Innate Immunity

Results indicate that bungee jumping leads to a catecholamine-independent immune suppressive phenotype and implicate noncanonical glucocorticoid receptor signal transduction as a major pathway linking human stress to impaired functioning of the human innate immune system.

Inward-attention meditation increases parasympathetic activity: a study based on heart rate variability.

Regular oscillating rhythms of the heart rate when the LF/HF ratio was small under meditation were observed and showed that such regular oscillations could also appear in the high-frequency band of HRV but with smaller amplitude.

Effects of a randomized controlled trial of transcendental meditation on components of the metabolic syndrome in subjects with coronary heart disease.

Use of TM for 16 weeks in CHD patients improved blood pressure and insulin resistance components of the metabolic syndrome as well as cardiac autonomic nervous system tone compared with a control group receiving health education, which may be a novel therapeutic target for the treatment of CHD.

Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia*

The findings strengthen the notion that the in vivo response to lipopolysaccharide is mediated by tissue-resident macrophages and that ex vivo stimulation does not accurately reflect the in vitro innate immune response.

Ageing Is Associated with a Prolonged Fever Response in Human Endotoxemia

In conclusion, ageing is associated with an altered acute-phase response including initial hyperreactivity, prolonged inflammatory activity, and prolonged fever response.