The Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation: A Comparison of Haloperidol and Olanzapine in Macaque Monkeys

@article{DorphPetersen2005TheIO,
  title={The Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation: A Comparison of Haloperidol and Olanzapine in Macaque Monkeys},
  author={Karl-Anton Dorph-Petersen and Joseph N. Pierri and James M. Perel and Zhuoxin Sun and Allan R. Sampson and David A. Lewis},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={1649-1661}
}
It is unclear to what degree antipsychotic therapy confounds longitudinal imaging studies and post-mortem studies of subjects with schizophrenia. To investigate this problem, we developed a non-human primate model of chronic antipsychotic exposure. Three groups of six macaque monkeys each were exposed to oral haloperidol, olanzapine or sham for a 17–27 month period. The resulting plasma drug levels were comparable to those seen in subjects with schizophrenia treated with these medications… 
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Mean curvature holds promise as a sensitive supplement to cortical thickness and surface area to detect complex structural brain abnormalities in antipsychotic-naïve schizophrenia patients.
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