The Influence of Aspirin on Release of Eoxin C4, Leukotriene C4 and 15-HETE, in Eosinophilic Granulocytes Isolated from Patients with Asthma

@article{James2013TheIO,
  title={The Influence of Aspirin on Release of Eoxin C4, Leukotriene C4 and 15-HETE, in Eosinophilic Granulocytes Isolated from Patients with Asthma},
  author={A. James and K. Daham and L. Backman and {\AA}sa Brunnstr{\"o}m and Tove Tingvall and M. Kumlin and C. Edenius and S. Dahl{\'e}n and B. Dahl{\'e}n and H. Cla{\'e}sson},
  journal={International Archives of Allergy and Immunology},
  year={2013},
  volume={162},
  pages={135 - 142}
}
  • A. James, K. Daham, +7 authors H. Claésson
  • Published 2013
  • Medicine
  • International Archives of Allergy and Immunology
  • Background: The effect of aspirin on the release of key arachidonic acid metabolites in activated eosinophils from subjects with aspirin-intolerant asthma (AIA) has not been investigated previously, despite the characteristic eosinophilia in AIA. Methods: Peripheral blood eosinophils were isolated from four groups of subjects: healthy volunteers (HV; n = 8), mild asthma (MA; n = 8), severe asthma (SA; n = 9) and AIA (n = 7). In the absence or presence of lysine-aspirin, eosinophils were… CONTINUE READING
    18 Citations
    Mechanisms of Aspirin-Intolerant Asthma: Identifying Inflammatory Pathways in the Pathogenesis of Asthma
    • H. Neighbour
    • Medicine
    • International Archives of Allergy and Immunology
    • 2013
    • 6
    On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.
    • 11
    Aspirin or other nonsteroidal inflammatory agent exacerbated asthma.
    • 35
    Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease.
    • 11
    Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.
    • 27
    A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics
    • 3
    • PDF
    Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas
    • 1

    References

    SHOWING 1-10 OF 45 REFERENCES
    Eoxins: a new inflammatory pathway in childhood asthma.
    • 50