The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer’s but Not Parkinson’s Disease or Dementia with Lewy Bodies

@inproceedings{Wennstrm2015TheIM,
  title={The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer’s but Not Parkinson’s Disease or Dementia with Lewy Bodies},
  author={Malin Wennstr{\"o}m and Yulia Surova and Sara Hall and Christer O S Nilsson and Lennart Minthon and Oskar Hansson and Henrietta M. Nielsen and David Bartr{\'e}s-Faz},
  booktitle={PloS one},
  year={2015}
}
A major difference in the revised diagnostic criteria for Alzheimer's disease (AD) is the incorporation of biomarkers to support a clinical diagnosis and allow the identification of preclinical AD due to AD neuropathological processes. However, AD-specific fluid biomarkers which specifically distinguish clinical AD dementia from other dementia disorders are still missing. Here we aimed to evaluate the disease-specificity of increased YKL-40 levels in cerebrospinal fluid (CSF) from AD patients… CONTINUE READING

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CSF biomarkers in neurodegenerative and vascular dementias

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