The Inflammasomes

  title={The Inflammasomes},
  author={Kate Schroder and Jürg Tschopp},

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Deregulated inflammasome signaling in disease
The role of inflammasomes in regulating innate and adaptive immune responses is reviewed with an emphasis on the role of these immune complexes in autoinflammatory disorders and autoimmune diseases such as colitis, type I diabetes, multiple sclerosis and vitiligo.
The inflammasome NLRs in immunity, inflammation, and associated diseases.
Determining exactly how the inflammasome is activated in these diseases and disease models remains a challenge, and a review presents and integrates recent progress in the field.
Molecular Mechanism of NLRP3 Inflammasome Activation
Three signaling pathways involving potassium efflux, generation of reactive oxygen species, and cathepsin B release are discussed, which drive innate immune response towards invading pathogens and cellular damage, and regulates adaptive immune response.
Molecular mechanisms regulating NLRP3 inflammasome activation
The NLRP3 inflammasome is linked with various human autoinflammatory and autoimmune diseases and may be a promising target for anti-inflammatory therapies, according to current understanding of the mechanisms by which it is activated in the cytosol.
Emerging inflammasome effector mechanisms
These non-canonical functions of caspase 1 illustrate the diverse mechanisms by which inflammasomes might contribute to innate immunity, repair responses and host defence.
Inflammasomes and Colorectal Cancer
This work reviews extant studies delving into different functions of inflammasomes in colorectal cancer development and concludes that infammasomes play contradictory roles in the development of inflammation-induced cancers.
Inflammasomes as Targets for Adjuvants
This review is focused on the mechanisms of action and the effects of adjuvants on inflammasome activation, which are necessary for the development of a healthy immune response against infectious diseases.
Post-translational regulation of inflammasomes
This review focuses on the emerging roles of post-translational modifications (PTMs) that regulate activation of the NLRP3, NLRP1, NLRC4, AIM2 and IFI16 inflammasomes.
Evasion of inflammasome activation by microbial pathogens.
This Review discusses a number of pathogens that have developed strategies to evade inflammasome activation as well as the potential infectious complications of therapeutic blockade of IL-1 pathways.
Mitochondria: Sovereign of inflammation?
  • J. Tschopp
  • Biology
    European journal of immunology
  • 2011
Mapping the connections between mitochondria, metabolism and inflammation is of great interest, as malfunctioning of this network is associated with many chronic inflammatory diseases.


The inflammasomes: guardians of the body.
The role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease are discussed.
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1β in the pathogenesis of type 2 diabetes.
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
It is proposed that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
An unexpected mechanism of inflammasome inhibition is revealed, whereby effector and memory T cells suppress potentially damaging inflammation, yet leave the primary inflammatory response, crucial for the onset of immunity, intact.
Cryopyrin activates the inflammasome in response to toxins and ATP
It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Inflammatory caspases and inflammasomes: master switches of inflammation
The role of inflammasomes and inflammatory caspases in innate immunity against pathogens, autoinflammatory syndromes and in the biology of reproduction is highlighted, underlining the importance of the NLR family members, NALPs, NAIP and IPAF.
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
It is demonstrated that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems, clarifying the molecular basis for the cytosolic response to flageLLin.
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1
It is shown that cell priming through multiple signaling receptors induces NLRP3 expression, which is identified to be a critical checkpoint for NLRP2 activation and signals provided by NF-κB activators are necessary but not sufficient forNLRP3 activation.