The Inflammasomes

@article{Schroder2010TheI,
  title={The Inflammasomes},
  author={Kate Schroder and Jürg Tschopp},
  journal={Cell},
  year={2010},
  volume={140},
  pages={821-832}
}
Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in… Expand

Paper Mentions

Deregulated inflammasome signaling in disease
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The role of inflammasomes in regulating innate and adaptive immune responses is reviewed with an emphasis on the role of these immune complexes in autoinflammatory disorders and autoimmune diseases such as colitis, type I diabetes, multiple sclerosis and vitiligo. Expand
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Three signaling pathways involving potassium efflux, generation of reactive oxygen species, and cathepsin B release are discussed, which drive innate immune response towards invading pathogens and cellular damage, and regulates adaptive immune response. Expand
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The NLRP3 inflammasome is linked with various human autoinflammatory and autoimmune diseases and may be a promising target for anti-inflammatory therapies, according to current understanding of the mechanisms by which it is activated in the cytosol. Expand
Inflammasomes as Targets for Adjuvants
TLDR
This review is focused on the mechanisms of action and the effects of adjuvants on inflammasome activation, which are necessary for the development of a healthy immune response against infectious diseases. Expand
Post-translational regulation of inflammasomes
TLDR
This review focuses on the emerging roles of post-translational modifications (PTMs) that regulate activation of the NLRP3, NLRP1, NLRC4, AIM2 and IFI16 inflammasomes. Expand
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TLDR
This Review discusses a number of pathogens that have developed strategies to evade inflammasome activation as well as the potential infectious complications of therapeutic blockade of IL-1 pathways. Expand
Mitochondria: Sovereign of inflammation?
  • J. Tschopp
  • Biology, Medicine
  • European journal of immunology
  • 2011
TLDR
Mapping the connections between mitochondria, metabolism and inflammation is of great interest, as malfunctioning of this network is associated with many chronic inflammatory diseases. Expand
Inflammasome activation and metabolic disease progression.
TLDR
Recent evidence is reviewed that demonstrates the important roles of NLRs and inflammasomes in response to metabolic stress in different tissues. Expand
Of inflammasomes and pathogens – sensing of microbes by the inflammasome
TLDR
The sensing mechanisms of the currently characterized inflammasome complexes are reviewed and recent advances in the molecular understanding of how microbial patterns are detected and discriminated from endogenous compounds by inflammal sensors are highlighted. Expand
Inflammasomes: Caspase-1-Activating Platforms with Critical Roles in Host Defense
TLDR
An overview of the distinct inflammasome complexes that are activated in a pathogen-specific manner are provided and the diverse strategies employed by viruses and bacteria to modulate inflammaome function are discussed. Expand
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