The Inflammasomes

@article{Schroder2010TheI,
  title={The Inflammasomes},
  author={Kate Schroder and Jürg Tschopp},
  journal={Cell},
  year={2010},
  volume={140},
  pages={821-832}
}
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3,460 Citations
Highly Influential Citations
189
Background Citations
907
Methods Citations
22
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7

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3,460 Citations

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References

SHOWING 1-10 OF 131 REFERENCES
The inflammasomes: guardians of the body.
TLDR
The role of NLRs, and in particular the inflammasomes, in the recognition of microbial and danger components and the role they play in health and disease are discussed.
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
TLDR
The participation of TXNIP in the NLRP3 inflammasome activation may provide a mechanistic link to the observed involvement of IL-1β in the pathogenesis of type 2 diabetes.
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
TLDR
It is proposed that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
TLDR
An unexpected mechanism of inflammasome inhibition is revealed, whereby effector and memory T cells suppress potentially damaging inflammation, yet leave the primary inflammatory response, crucial for the onset of immunity, intact.
Cryopyrin activates the inflammasome in response to toxins and ATP
TLDR
It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Inflammatory caspases and inflammasomes: master switches of inflammation
TLDR
The role of inflammasomes and inflammatory caspases in innate immunity against pathogens, autoinflammatory syndromes and in the biology of reproduction is highlighted, underlining the importance of the NLR family members, NALPs, NAIP and IPAF.
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
TLDR
It is demonstrated that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems, clarifying the molecular basis for the cytosolic response to flageLLin.
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1
TLDR
It is shown that cell priming through multiple signaling receptors induces NLRP3 expression, which is identified to be a critical checkpoint for NLRP2 activation and signals provided by NF-κB activators are necessary but not sufficient forNLRP3 activation.
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
...
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