The Inflammasomes

@article{Schroder2010TheI,
  title={The Inflammasomes},
  author={Kate Schroder and Jürg Tschopp},
  journal={Cell},
  year={2010},
  volume={140},
  pages={821-832}
}
Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in… Expand
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