The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells

@article{Steinman2000TheIO,
  title={The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells},
  author={Ralph Marvin Steinman and Shannon J. Turley and Ira Mellman and Kayo Inaba},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={411 - 416}
}
What makes a protein immunogenic, particularly for strong T cell–mediated immunity? To a first approximation, this determination seems to be made by dendritic cells (DCs). Immature DCs, as in skin (1–4), lung (5), blood (6, 7), and spleen (7, 8), take up proteins, immune complexes, microbes, and dying cells. However, in order to use these antigens to stimulate a T cell response, the DCs must undergo a characteristic process of terminal differentiation called “maturation.” The known stimuli for… CONTINUE READING