The Induction of Prostaglandin E2 Production, Interleukin-6 Production, Cell Cycle Arrest, and Cytotoxicity in Primary Oral Keratinocytes and KB Cancer Cells by Areca Nut Ingredients Is Differentially Regulated by MEK/ERK Activation*

@article{Chang2004TheIO,
  title={The Induction of Prostaglandin E2 Production, Interleukin-6 Production, Cell Cycle Arrest, and Cytotoxicity in Primary Oral Keratinocytes and KB Cancer Cells by Areca Nut Ingredients Is Differentially Regulated by MEK/ERK Activation*},
  author={M. Chang and Hui-Lin Wu and Jang-Jaer Lee and Po-Hsuen Lee and Hsiao-Hwa Chang and L. Hahn and B. Lin and Yi-Jane Chen and J. Jeng},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={50676 - 50683}
}
There are about 200–600 million betel quid (BQ) chewers in the world. BQ chewing is one of the major risk factor of hepatocarcinoma, oropharyngeal, and esophagus cancers in Taiwan, India, and Southeast Asian countries. Thus, the precise molecular mechanisms deserve investigation. We used cultured primary keratinocytes and KB cells, RT-PCR, flow cytometry, Western blotting, and ELISA to evaluate whether alterations in early gene expression is crucial in the carcinogenic processes of BQ. We… Expand
Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells
Arecoline-stimulated placenta growth factor production in gingival epithelial cells: modulation by curcumin.
Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components.
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