The Induction of Autoimmunity in Rabbits following Injection of Heterologous or Altered Homologous Thyroglobulin

Abstract

Experimental autoimmunity was produced in rabbits following injection of altered homologous thyroglobulin. The thyroglobulin was altered by coupling to chemically defined haptens and by heating. With some preparations antibody to native thyroglobulin as well as thyroid lesions were produced. Injections of thyroglobulin coupled to the diazonium derivatives… (More)

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