The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells

@inproceedings{Besanon2017TheIA,
  title={The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells},
  author={Alix Besançon and Marije C. Baas and Tania Goncalves and Fabrice Valette and Herman Waldmann and Lucienne Chatenoud and Sylvaine You},
  booktitle={Front. Immunol.},
  year={2017}
}
Therapeutic tolerance to self-antigens or foreign antigens is thought to depend on constant vigilance by Foxp3+ regulatory T cells (Tregs). Previous work using a pancreatic islet allograft model and a short pulse of CD3 antibody therapy has shown that CD8+ T cells become anergic and use TGFβ and coinhibitory signaling as their contribution to the tolerance process. Here, we examine the role of CD4+ T cells in tolerization by CD3 antibodies. We show that both Foxp3+ Tregs and CD4+ T cell anergy… CONTINUE READING
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