The Incubation Period of Kuru

  title={The Incubation Period of Kuru},
  author={J{\'e}r{\^o}me N Huillard d'Aignaux and Simon Cousens and Jean Maccario and Dominique Costagliola and Michael P. Alpers and Peter G. Smith and Annick Alp{\'e}rovitch},
Background. Kuru is a transmissible spongiform encephalopathy that was identified in Papua New Guinea in the late 1950s. Several thousand cases of the disease occurred during a period of several decades. Epidemiologic investigations implicated ritual endocannibalistic funeral feasts as the likely route through which the infectious agent was spread. Methods. We estimated the incubation period distribution of kuru using a back-calculation model and explored the relation among sex, age at… 

Pathogenesis and prevalence of variant Creutzfeldt–Jakob disease

  • D. Hilton
  • Medicine
    The Journal of pathology
  • 2006
The importance of developing a reliable blood test for vCJD and the continued need for surveillance are highlighted, as it is known from iatrogenic CJD and kuru that human prion disease can have incubation periods of up to 40 years.

Epidemiological mechanisms of genetic resistance to kuru

A model that combines the dynamics of kuru transmission and the population genetics of human resistance indicates that human resistance arises from a combination of both a longer incubation period and reduced susceptibility to infection.

The epidemiology of variant Creutzfeldt-Jakob disease.

The development of a test that could be used on easily accessible tissue to detect infection early in the incubation period would not only advance understanding of the epidemiology of infection with the agent but would also aid the implementation of control measures to prevent potential iatrogenic spread.

The predictability of the epidemic of variant Creutzfeldt-Jakob disease by back-calculation methods

We present a back-calculation analysis of the variant Creutzfeldt-Jakob (vCJD) epidemic in the UK to estimate the number of infected individuals and to explore the likely future incidence of the

The epidemics of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: current status and future prospects.

Better control measures are necessary to guard against the possibility of iatrogenic transmission through blood transfusion or contaminated surgical instruments, and these measures will required sensitive and specific, diagnostic tests and improved decontamination methods.

Title Early efforts in modeling the incubation period of infectiousdiseases with an acute course of illness

Analysis using well-defined short periods of exposure with appropriate statistical methods is critical when the exact time of exposure is unknown, and when assuming a specific distribution for the incubation period is assumed, comparisons using different distributions are needed in addition to estimations using different datasets.

Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility

Results of a survey of lymphoreticular tissues have suggested a substantially higher prevalence of variant Creutzfeldt–Jakob disease than expected from the clinical data alone, but predictions of future cases of vCJD remain uncertain.

Genetics and infectious disease: convergence at the prion.

Supporting evidence is provided from clusters of kuru cases that have been linked with known cannibalistic feasts, establishing the incubation period as being at least 30 years.

Early efforts in modeling the incubation period of infectious diseases with an acute course of illness

Analysis using well-defined short periods of exposure with appropriate statistical methods is critical when the exact time of exposure is unknown, and when assuming a specific distribution for the incubation period is assumed, comparisons using different distributions are needed.



Unconventional viruses and the origin and disappearance of kuru.

Kuru established that virus infections of man could, after long delay, produce chronic degenerative disease and disease with apparent heredofamilial patterns of occurrence, and with none of the inflammatory responses regularly associated with viral infections.

Incubation period of Creutzfeldt–Jakob disease in human growth hormone recipients in France

The short mean incubation period of CJD in French hGH recipients may be due to high infectivity in hormone lots, and estimates of the 95th percentile indicate that the number of hGH-related CJD cases may continue to increase in the coming years.

Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update.

It is confirmed that the onset of clinical signs and pathological changes in the central nervous system (CNS) occur at approximately the same time, and the earliest pathological change, the presence of abnormal PrP 32 months after inoculation, coincided with the earliest detected infectivity in the CNS.

Changing patterns of kuru: epidemiological changes in the period of increasing contact of the Fore people with western civilization.

Analysis of the records of kuru from 1957 to 1964 shows that there has been a progressive decline in kuru mortality and incidence over this period, present in adults and children, but most marked among the latter, and especially so in the youngest age group.

Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent

It is shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (BSE) produces a characteristic pattern of disease in mice that is retained after experimental passage through a variety of intermediate species, providing strong evidence that the same agent strain is involved in both BSE and vCJD.

The Natural Incubation Period of Kuru and the Episodes of Transmission in Three Clusters of Patients

Epidemiological data were collected on the slow virus disease, kuru, among the Fore cultural and linguistic group in Papua New Guinea from 65 kuru patients who died or were diagnosed between 1977 and

3 Bioassays of Prions

Prior to the experimental transmission of scrapie to goats inoculated with tissue extracts prepared from sheep with scrapie, no experimental studies of the disease were possible and limited information was obtained.

Genetic control of scrapie: incubation period and plaque formation in I mice.

The I strain was shown to fulfil the criteria that are characteristic of mouse strains with the p7 allele of Sinc: a comparatively long incubation period for ME7 and a short incubationperiod for 22A.

Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease.

If nvCJD behaves like kuru, future cases may begin to occur in older individuals with heterozygous codon 129 genotypes and signal a maturing evolution of the nv CJD "epidemic," which may have less (or at least less readily identified) amyloid plaque formation.