The Incubation Period of Kuru

  title={The Incubation Period of Kuru},
  author={J{\'e}r{\^o}me N Huillard d'Aignaux and Simon Cousens and Jean Maccario and Dominique Costagliola and Michael P. Alpers and Peter G. Smith and Annick Alp{\'e}rovitch},
Background. Kuru is a transmissible spongiform encephalopathy that was identified in Papua New Guinea in the late 1950s. Several thousand cases of the disease occurred during a period of several decades. Epidemiologic investigations implicated ritual endocannibalistic funeral feasts as the likely route through which the infectious agent was spread. Methods. We estimated the incubation period distribution of kuru using a back-calculation model and explored the relation among sex, age at… 
The epidemiology of variant Creutzfeldt-Jakob disease.
The development of a test that could be used on easily accessible tissue to detect infection early in the incubation period would not only advance understanding of the epidemiology of infection with the agent but would also aid the implementation of control measures to prevent potential iatrogenic spread.
The predictability of the epidemic of variant Creutzfeldt-Jakob disease by back-calculation methods
We present a back-calculation analysis of the variant Creutzfeldt-Jakob (vCJD) epidemic in the UK to estimate the number of infected individuals and to explore the likely future incidence of the
Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility
Results of a survey of lymphoreticular tissues have suggested a substantially higher prevalence of variant Creutzfeldt–Jakob disease than expected from the clinical data alone, but predictions of future cases of vCJD remain uncertain.
Genetics and infectious disease: convergence at the prion.
Supporting evidence is provided from clusters of kuru cases that have been linked with known cannibalistic feasts, establishing the incubation period as being at least 30 years.
Early efforts in modeling the incubation period of infectious diseases with an acute course of illness
Analysis using well-defined short periods of exposure with appropriate statistical methods is critical when the exact time of exposure is unknown, and when assuming a specific distribution for the incubation period is assumed, comparisons using different distributions are needed.
Bovine Spongiform Encephalopathy An Updated Scientific Literature Review
Variant CJD cases continue to be diagnosed in the UK but the rate of increase in cases is not increasing, leading some experts to revise downward predictions of the future extent of the epidemic.
Clinical aspects of variant Creutzfeldt-Jakob disease.
Factors determining the pattern of the variant Creutzfeldt-Jakob disease (vCJD) epidemic in the UK
The results demonstrate that, while the magnitude of the uncertainty has decreased dramatically since 1996, it is still not possible to predict with any degree of accuracy the final magnitude of this epidemic, with the 95% confidence interval for future cases being from 10 to 7000 deaths.
Predicting incidence of variant Creutzfeldt-Jakob disease from UK dietary exposure to bovine spongiform encephalopathy for the 1940 to 1969 and post-1969 birth cohorts.
The incubation period, transmission barrier, and short-term vCJD predictions for methionine homozygotes in 1940-1969 and post-1969 birth cohorts are investigated by use of gender- and age-specific exposure intensities to bovine spongiform encephalopathy (BSE).


Unconventional viruses and the origin and disappearance of kuru.
Kuru established that virus infections of man could, after long delay, produce chronic degenerative disease and disease with apparent heredofamilial patterns of occurrence, and with none of the inflammatory responses regularly associated with viral infections.
Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update.
It is confirmed that the onset of clinical signs and pathological changes in the central nervous system (CNS) occur at approximately the same time, and the earliest pathological change, the presence of abnormal PrP 32 months after inoculation, coincided with the earliest detected infectivity in the CNS.
Changing patterns of kuru: epidemiological changes in the period of increasing contact of the Fore people with western civilization.
Analysis of the records of kuru from 1957 to 1964 shows that there has been a progressive decline in kuru mortality and incidence over this period, present in adults and children, but most marked among the latter, and especially so in the youngest age group.
Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
It is shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (BSE) produces a characteristic pattern of disease in mice that is retained after experimental passage through a variety of intermediate species, providing strong evidence that the same agent strain is involved in both BSE and vCJD.
The Natural Incubation Period of Kuru and the Episodes of Transmission in Three Clusters of Patients
Epidemiological data were collected on the slow virus disease, kuru, among the Fore cultural and linguistic group in Papua New Guinea from 65 kuru patients who died or were diagnosed between 1977 and
Phenotype-genotype studies in kuru: implications for new variant Creutzfeldt-Jakob disease.
If nvCJD behaves like kuru, future cases may begin to occur in older individuals with heterozygous codon 129 genotypes and signal a maturing evolution of the nv CJD "epidemic," which may have less (or at least less readily identified) amyloid plaque formation.
The age incidence of kuru
  • N. McArthur
  • Environmental Science
    Annals of human genetics
  • 1964
The incidence of kuru in the populations of the South Fore and Gimi census divisions in the Eastern Highlands of New Guinea has been analysed and mortality and morbidity rates increase fairly steadily with age, attaining their maximum value at about 45 years of age, and then decline.
Transmission of scrapie in hamsters.
Results provide compelling evidence for oral transmission of scrapie and may offer new insights into the spread of kuru by cannibalism among the Fore people and their neighbors and have implications for understanding the sporadic occurrence and worldwide distribution of Creutzfeldt-Jakob disease.
Censoring in an epidemic with an application to hemophilia-associated AIDS.
A two-stage parametric regression model is proposed for the analysis of cohort studies during an epidemic in which the exact times of infection cannot be ascertained and it was found that hemophiliacs with severe Type A hemophilia were at highest risk of infection, and therisk of infection increased sharply in the early 1980s.