The Increase in Plasma Levels of Nε-(Carboxymethyl)lysine During Icodextrin Treatment of Peritoneal Dialysis Patients Is Not Associated with Increased Plasma Levels of Vascular Cell Adhesion Molecule-1

  title={The Increase in Plasma Levels of N$\epsilon$-(Carboxymethyl)lysine During Icodextrin Treatment of Peritoneal Dialysis Patients Is Not Associated with Increased Plasma Levels of Vascular Cell Adhesion Molecule-1},
  author={Jeroen P. Kooman and Casper G. Schalkwijk and Constantijn J.A.M. Konings},
  journal={Peritoneal Dialysis International},
  pages={410 - 411}
Editor: It has been hypothesized that an increase in advanced glycation end products (AGEs) contributes to vascular damage, or peritoneal damage in dialysis patients (1), by endothelial or mesothelial cell activation (2). It was shown that the AGE product Nε-(carboxymethyl)lysine (CML) could induce endothelial and mesothelial activation, as indicated by an increased expression of vascular cell adhesion molecule-1 (VCAM-1) through activation of the receptor of AGE (RAGE) (2). Moreover, in a… Expand
4 Citations
The new peritoneal dialysis solutions: friends only, or foes in part?
Improved biocompatibility of the new peritoneal dialysis solutions is indicated; a number of studies, however, detected no superiority when levels of accepted markers of biOCompatibility, such as vascular endothelial growth factor or hyaluronic acid were measured. Expand
Comparison of clinical effects between icodextrin and glucose solutions on outcomes of peritoneal dialysis: systematic review and meta-analysis of randomized controlled trials
Icodextrin could relieve uncontrolled fluid overload without adding risk and a significant effect on clinically relevant outcomes such as technical survival and overall patient survival was not suggested. Expand
Biocompatible dialysis fluids for peritoneal dialysis.
Use of neutral pH, low GDP PD solution led to greater urine output and higher residual renal function after use exceeded 12 months, and Icodextrin prescription improved peritoneal ultrafiltration and mitigated uncontrolled fluid overload. Expand
Biocompatible dialysis fluids for peritoneal dialysis.
It is uncertain whether neutral pH, low GDP PD solution use led to any differences in peritonitis occurrence, hospitalisation, adverse events, or inflow pain. Expand


N ϵ-(carboxymethyl)lysine, N ϵ-(carboxyethyl)lysine and vascular cell adhesion molecule-1 (VCAM-1) in relation to peritoneal glucose prescription and residual renal function; a study in peritoneal dialysis patients
The effect of rGFR, which does not appear to be mediated through lipid peroxidation pathways, on effluent levels of CML appears to outweigh the effect of the PD treatment, and the relation between residual glomerular filtration rate (rGFR), malondialdehyde (MDA) and peritoneal glucose prescription and absorption with serum levels of VCAM-1 and with well characterized AGEs is investigated. Expand
Influence of Icodextrin on Plasma and Dialysate Levels of N∊-(Carboxymethyl)Lysine and N∊-(Carboxyethyl)Lysine
Rationale Standard peritoneal glucose solutions may induce the formation of advanced glycation end products (AGEs). Preliminary data suggest that AGE formation may be less with the use of polyglucoseExpand
AGEs bind to mesothelial cells via RAGE and stimulate VCAM-1 expression.
The AGE-RAGE interaction resulted in HPMC activation, which may promote local inflammation, and thus is implicated in the peritoneal injury found in long-term PD patients. Expand
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications.
Uremia may be described as a state of carbonyl overload or "carbonyl stress" resulting from either increased oxidation of carbohydrates and lipids (oxidative stress) or inadequate detoxification or inactivation of reactive carbonyL compounds derived from both carbohydrates andlipids by oxidative and nonoxidatives. Expand
Plasma Levels of AGE Peptides in Type 1 Diabetic Patients Are Associated with Serum Creatinine and Not with Albumin Excretion Rate: Possible Role of AGE Peptide‐Associated Endothelial Dysfunction
It is shown that plasma levels of AGE peptides rise with renal impairment, as determined by serum creatinine, which may suggest an involvement of A GE peptides in the acceleration of cardiovascular complications in type 1 diabetic patients with kidneys impairment. Expand
RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes.
A new murine model for the study of atherosclerosis in type 2 diabetes is established and important roles for RAGE in proatherogenic mechanisms in hyperglycemia triggered by insulin resistance are highlighted. Expand
Effect of icodextrin on volume status, blood pressure and echocardiographic parameters: a randomized study.
In this randomized open-label study, the use of icodextrin resulted in a significant reduction in ECW and LVM, and the effect on peritoneal membrane characteristics was related to the initial fluid state of the patient. Expand
Effect of increased dialysate fill volume on peritoneal fluid and solute transport.
The results indicate that decreased net ultrafiltration volume associated with higher dialysate fill volume (due to higher IPP and higher peritoneal fluid absorption) could be avoided if hypertonic glucose solutions are used. Expand
Effects of arterial and venous pressure alterations on transcapillary fluid exchange during raised tissue pressure
Tissue volume is increased by raised an decreased by lowered PA, the latter may be of use to decrease ICP in the injured brain and the results indicate that PEEP or head elevation will not influence ICP from the venous side if CVP<ICP. Expand
The role of arterial and venous pressure for volume regulation of an organ enclosed in a rigid compartment with application to the injured brain
Tissue and perfusion pressure during corresponding interventions in an organ enclosed in a rigid compartment with capillaries permeable for electrolytes and impaired autoregulation, conditions comparable to those present in the injured brain are evaluated. Expand