The Increase in Plasma Levels of Nε-(Carboxymethyl)lysine During Icodextrin Treatment of Peritoneal Dialysis Patients Is Not Associated with Increased Plasma Levels of Vascular Cell Adhesion Molecule-1

@article{Kooman2006TheII,
  title={The Increase in Plasma Levels of N$\epsilon$-(Carboxymethyl)lysine During Icodextrin Treatment of Peritoneal Dialysis Patients Is Not Associated with Increased Plasma Levels of Vascular Cell Adhesion Molecule-1},
  author={Jeroen P. Kooman and Casper G. Schalkwijk and Constantijn J.A.M. Konings},
  journal={Peritoneal Dialysis International},
  year={2006},
  volume={26},
  pages={410 - 411}
}
Editor: It has been hypothesized that an increase in advanced glycation end products (AGEs) contributes to vascular damage, or peritoneal damage in dialysis patients (1), by endothelial or mesothelial cell activation (2). It was shown that the AGE product Nε-(carboxymethyl)lysine (CML) could induce endothelial and mesothelial activation, as indicated by an increased expression of vascular cell adhesion molecule-1 (VCAM-1) through activation of the receptor of AGE (RAGE) (2). Moreover, in a… Expand
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