The Incidence of DNA Double-Strand Breaks Is Higher in Late-Cleaving and Less Developmentally Competent Porcine Embryos.

@article{Bohrer2015TheIO,
  title={The Incidence of DNA Double-Strand Breaks Is Higher in Late-Cleaving and Less Developmentally Competent Porcine Embryos.},
  author={Rodrigo Camponogara Bohrer and Ana Rita de Sousa Coutinho and Raj Duggavathi and Vilceu Bordignon},
  journal={Biology of reproduction},
  year={2015},
  volume={93 3},
  pages={59}
}
Studies in different species, including human, mice, bovine, and swine, demonstrated that early-cleaving embryos have higher capacity to develop to the blastocyst stage and produce better quality embryos with superior capacity to establish pregnancy than late-cleaving embryos. It has also been shown that experimentally induced DNA damage delays embryo cleavage kinetics and reduces blastocyst formation. To gain additional insights into the effects of genome damage on embryo cleavage kinetics and… CONTINUE READING
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