The In(put)s and Out(put)s of the Drosophila Circadian Clock

@article{Boothroyd2008TheIA,
  title={The In(put)s and Out(put)s of the Drosophila Circadian Clock},
  author={Catharine E. Boothroyd and Michael W. Young},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1129}
}
Circadian clocks are aligned to the 24‐h environmental day via zeitgebers, and information from the clock must be relayed to the rest of the organism. Recent studies addressing temperature as an input to, and the generation of rhythmic gene expression as an output from, the Drosophila central clock are discussed. 
View on Wiley
ncbi.nlm.nih.gov
32 Citations
Background Citations
14
Methods Citations
1

32 Citations

Citation Type

Citation Type

Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock
TLDR
New experiments using conditional mouse genetics suggest that resetting of the circadian system occurs in a more “federated” and tissue‐specific fashion, which allows for increased noise resistance and plasticity of circadian timekeeping under natural conditions.
Isolation of new genes involved in temperature synchronization of the circadian clock of Drosophila melanogaster
TLDR
It is shown that genes important for entrainment of adult locomotor behaviour to temperature do not play the same role in regulating the synchronization of eclosion, as well as a behavioural analysis of the already-known “temperature-mutant” nocte.
Regulation of Drosophila rest:activity rhythms by a microRNA and aging
TLDR
The studies described in this thesis contribute to understanding of the molecular underpinnings of circadian output and suggest that such outputs are affected by aging, and may contribute to finding treatments for clock dysregulation or age-related circadian disorders.
A comparative view of insect circadian clock systems
TLDR
A variety of clock mechanisms derived from an ancestral one is found in various insect orders, including Drosophila, where autoregulatory negative feedback loops that consist of clock genes, such as period and timeless are believed to create 24-h rhythmicity.
Temperature Entrainment of Drosophila's Circadian Clock Involves the Gene nocte and Signaling from Peripheral Sensory Tissues to the Brain
Circadian control of global gene expression patterns.
TLDR
The impacts transcriptomics have had on the understanding of the clock and how this molecular clock connects with system-level circadian responses are reviewed and the discoveries made possible by high-throughput RNA assays, the network approaches used to investigate these large transcript datasets, and potential future directions are explored.
The circadian system: Plasticity at many levels
Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii
BackgroundInternal circadian (circa, about; dies, day) clocks enable organisms to maintain adaptive timing of their daily behavioral activities and physiological functions. Eukaryotic clocks consist…
Control of Sleep by Cyclin A and Its Regulator
TLDR
It is shown thatcyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster.
Cryptochrome-Positive and -Negative Clock Neurons in Drosophila Entrain Differentially to Light and Temperature
TLDR
There are 2 types of clock neurons having differential sensitivities to light and temperature, and CRY is a key component for the preferential entrainment to light.
...
1
2
3
4
...

References

SHOWING 1-10 OF 60 REFERENCES
Assignment of circadian function for the Neurospora clock gene frequency
TLDR
Traditional circadian entrainment protocols are used to distinguish between under- or overexpression of a gene product can result in arrhythmicity, whether the protein is part of the oscillator or substantially part of a rhythmically expressed input pathway.
Microbial circadian oscillatory systems in Neurospora and Synechococcus: models for cellular clocks.
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.
TLDR
The Drosophila CLOCK protein was shown to induce transcription of the circadian rhythm genes period and timeless, and PERIOD and TIMELESS proteins blocked dCLOCK's ability to transactivate their promoters via the E-box.
A role for the proteasome in the light response of the timeless clock protein.
TLDR
The sensitivity of TIM regulation by light was tested and suggested that TIM is degraded through a ubiquitin-proteasome mechanism, and TIM was ubiquitinated in response to light in cultured cells.
How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length
Differential Effects of Light and Heat on theDrosophila Circadian Clock Proteins PER and TIM
TLDR
These findings can account for the lack of apparent steady-state shifts in Drosophila behavioral rhythms by heat pulses applied in the late night and strongly suggest that stimulus-induced changes in the speed of circadian clocks can contribute to phase-shifting responses.
Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C
Drosophila melanogaster locomotor activity responds to different seasonal conditions by thermosensitive regulation of splicing of a 3′ intron in the period mRNA transcript. Here we demonstrate that…
Novel Insights into the Regulation of the Timeless Protein
TLDR
It is proposed that TIM drives cycles of PER expression by regulating its stability, and in turn, PER retains TIM in the nucleus, either for the regulation of its own stability or for a novel nuclear role of TIM.
Circadian Regulation of Gene Expression Systems in the Drosophila Head
A Temperature-Dependent Timing Mechanism is Involved in the Circadian System that Drives Locomotor Rhythms in the Fruit Fly Drosophila melanogaster
TLDR
It is suggested that per01 and tim01 flies have a temperature-entrainable weak oscillatory mechanism and that the per-less oscillatory mechanisms may require dClk and cyc, which are also involved in determining the light-associated temperature preference in per 01 and tim 01 flies.
...
1
2
3
4
5
...