The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain

@inproceedings{Guo2017TheIR,
  title={The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain},
  author={Huichen Guo and Mei Huang and Quan Yuan and Yanquan Wei and Yuan Gao and Lejiao Mao and Lingjun Gu and Yong Wah Tan and Yanxin Zhong and Dingxiang Liu and Shiqi Sun},
  booktitle={PloS one},
  year={2017}
}
Lipid raft is an important element for the cellular entry of some viruses, including coronavirus infectious bronchitis virus (IBV). However, the exact role of lipid rafts in the cellular membrane during the entry of IBV into host cells is still unknown. In this study, we biochemically fractionated IBV-infected cells via sucrose density gradient centrifugation after depleting plasma membrane cholesterol with methyl-β-cyclodextrin or Mevastatin. Our results demonstrated that unlike IBV non… CONTINUE READING

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