The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases
@article{Simopoulos2008TheIO, title={The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases}, author={Artemis P. Simopoulos}, journal={Experimental Biology and Medicine}, year={2008}, volume={233}, pages={674 - 688} }
Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of ~1 whereas in Western diets the ratio is 15/1–16.7/1. Western diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which human beings evolved and their genetic patterns were established. Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio…
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References
SHOWING 1-10 OF 160 REFERENCES
Omega-6/omega-3 essential fatty acid ratio: the scientific evidence
- Medicine
- 2003
The ratio of Omega 6/Omega 3 Essential Fatty Acids - Evolutionary Aspects and Brain-Related Functions and Dietary Prevention of Coronary Heart Disease and Cancer are reviewed.
Omega-3 fatty acids in health and disease and in growth and development.
- Medicine, BiologyThe American journal of clinical nutrition
- 1991
Omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors, which is essential for the normal functional development of the retina and brain, particularly in premature infants.
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
- Medicine, BiologyJournal of the American College of Nutrition
- 2002
Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases.
Essential fatty acids in health and chronic disease.
- MedicineThe American journal of clinical nutrition
- 1999
Alpha-linolenic acid, found in green leafy vegetables, flaxseed, rapeseed, and walnuts, desaturates and elongates in the human body to EPA and DHA and by itself may have beneficial effects in health and in the control of chronic diseases.
Omega-3 fatty acids and antioxidants in edible wild plants.
- Biology, MedicineBiological research
- 2004
The role of ALA in human nutrition becomes important in terms of long-term dietary intake because of its inhibitory effects on the clotting activity of platelets, on their response to thrombin, and on the regulation of arachidonic acid metabolism.
Omega‐3 fatty acids in wild plants, nuts and seeds
- Medicine
- 2002
The present paper identifies multiple sources ofALA from plants, legumes, nuts and seeds and emphasizes the importance of the ratio of omega-6 to omega-3 fatty acids for proper desaturation and elongation of ALA into EPA and DHA.
Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults
- Medicine, PsychologyPsychosomatic medicine
- 2007
Diets with high n-6:n-3 PUFA ratios may enhance the risk for both depression and inflammatory diseases.
Evolutionary aspects of omega-3 fatty acids in the food supply.
- MedicineProstaglandins, leukotrienes, and essential fatty acids
- 1999
Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects.
- Medicine, BiologyThe American journal of clinical nutrition
- 2007
Increased intakes of dietary ALA elicit antiinflammatory effects by inhibiting IL-6, IL-1beta, and TNF-alpha production in cultured PBMCs, and changes in PBMC ALA and eicosapentaenoic acid are associated with beneficial changes in T NF-alpha release.