The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse

@article{Enderling2009TheIO,
  title={The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse},
  author={H. Enderling and D. Park and L. Hlatky and P. Hahnfeldt},
  journal={Mathematical Modelling of Natural Phenomena},
  year={2009},
  volume={4},
  pages={117-133}
}
  • H. Enderling, D. Park, +1 author P. Hahnfeldt
  • Published 2009
  • Biology
  • Mathematical Modelling of Natural Phenomena
  • Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpop- ulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited life span… CONTINUE READING

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