The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse

  title={The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse},
  author={H. Enderling and D. Park and L. Hlatky and P. Hahnfeldt},
  journal={Mathematical Modelling of Natural Phenomena},
  • H. Enderling, D. Park, +1 author P. Hahnfeldt
  • Published 2009
  • Biology
  • Mathematical Modelling of Natural Phenomena
  • Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpop- ulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited life span… CONTINUE READING

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    Publications referenced by this paper.
    Identification of a cancer stem cell in human brain tumors.
    • 4,497
    • PDF
    Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
    • 882
    • PDF
    A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype.
    • 368
    • PDF
    Prospective identification of tumorigenic breast cancer cells
    • 8,885
    • PDF
    Prostate cancer stem cells: a new target for therapy.
    • 337
    Identification of human brain tumour initiating cells
    • 6,335
    • PDF
    The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
    • 1,421
    • PDF
    The universal dynamics of tumor growth.
    • 307
    Exploring the role of cancer stem cells in radioresistance
    • 640
    A mathematical model of breast cancer development, local treatment and recurrence.
    • 156
    • PDF