The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse

@inproceedings{Enderling2009TheIO,
  title={The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radioresponse},
  author={Heiko Enderling and Doyoung Park and Lynn Hlatky and Philip Hahnfeldt},
  year={2009}
}
Tumor growth and progression is a complex phenomenon dependent on the interaction of multiple intrinsic and extrinsic factors. Necessary for tumor development is a small subpopulation of potent cells, so-called cancer stem cells, that can undergo an unlimited number of cell divisions and which are proposed to divide symmetrically with a small probability to produce more cancer stem cells. We show that the majority of cells in a tumor must indeed be non-stem cancer cells with limited life span… CONTINUE READING
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