The Importance of Nitric Oxide and Arginase in the Pathogenesis of Acute Neuroinflammation: Are Those Contra Players with the Same Direction?

@article{Ljubisavljevi2014TheIO,
  title={The Importance of Nitric Oxide and Arginase in the Pathogenesis of Acute Neuroinflammation: Are Those Contra Players with the Same Direction?},
  author={Srdjan Ljubisavljevi{\'c} and Ivana D Stojanovi{\'c} and Radmila Pavlovic and Du{\vs}ica Pavlovi{\'c}},
  journal={Neurotoxicity Research},
  year={2014},
  volume={26},
  pages={392-399}
}
To investigate the concentrations of nitric oxide (NO) products (NOx) and arginase activity in acute neuroinflammation, we analyzed cerebrospinal fluid (CSF) and plasma of clinically isolated syndrome (CIS) and relapsing remitting multiple sclerosis (RRMS) patients, who were divided into groups on the basis of clinical and radiological disease activity. The NOx levels, in both, CSF and plasma, were increased in CIS (p = 0.0015, p = 0.0014, respectively) and RRMS group (p = 0.002, p = 0.0019… CONTINUE READING

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