The Importance of Local Chemical Structure for Chemical Metabolism by Human Uridine 5'-Diphosphate-Glucuronosyltransferase

@article{Sorich2006TheIO,
  title={The Importance of Local Chemical Structure for Chemical Metabolism by Human Uridine 5'-Diphosphate-Glucuronosyltransferase},
  author={Michael J. Sorich and Ross A. McKinnon and John O. Miners and Paul A. Smith},
  journal={Journal of chemical information and modeling},
  year={2006},
  volume={46 6},
  pages={2692-7}
}
The uridine 5'-diphosphate- (UDP-)glucuronosyltransferase (UGT) family of enzymes catalyzes the conjugation of chemicals containing a suitable nucleophilic atom with glucuronic acid. Despite the importance of glucuronidation as an elimination and detoxification mechanism for drugs, environmental chemicals, and endogenous compounds, the structural features of substrates that confer isoform selectivity are poorly understood. The relationship between the local molecular structure of nucleophilic… CONTINUE READING
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