The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer.


CD44 is a cell surface HA-binding glycoprotein that is overexpressed to some extent by almost all tumors of epithelial origin and plays an important role in tumor initiation and metastasis. CD44 is a compelling marker for cancer stem cells of many solid malignancies. In addition, interaction of HA and CD44 promotes EGFR-mediated pathways, consequently… (More)
DOI: 10.1155/2016/2087204