The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

@inproceedings{Kaczorowski2011TheIO,
  title={The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling},
  author={Gregory J. Kaczorowski and Maria Luiza Garcia and Jacob Bode and Stephen D. Hess and Umesh A. Patel},
  booktitle={Front. Pharmacol.},
  year={2011}
}
Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be minimized can save valuable time and money during the preclinical lead optimization phase if pivotal questions are asked beyond the usual profiling at hERG. The best data for critical evaluation of… CONTINUE READING