The Implications of Hyponitroxia in Cancer

  title={The Implications of Hyponitroxia in Cancer},
  author={Bryan T. Oronsky and Gary R. Fanger and Neil C. Oronsky and Susan J. Knox and Jan J. Scicinski},
  booktitle={Translational oncology},
Tumors are spatially heterogeneous, with regions of relative hypoxia and normoxia. The tumor microenvironment is an important determinant of both tumor growth and response to a variety of cytotoxic and targeted therapies. In the tumor microenvironment, reactive oxygen species and nitric oxide (NO) are important mediators of the level of expression of many transcription factors and signaling cascades that affect tumor growth and responses to therapy. The primary objective of this review is to… CONTINUE READING
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