The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast

@article{Warnecke2008TheIO,
  title={The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast},
  author={Tobias Warnecke and Nizar N. Batada and Laurence D. Hurst},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={R75 - 633}
}
Coding sequence evolution was once thought to be the result of selection on optimal protein function alone. Selection can, however, also act at the RNA level, for example, to facilitate rapid translation or ensure correct splicing. Here, we ask whether the way DNA works also imposes constraints on coding sequence evolution. We identify nucleosome positioning as a likely candidate to set up such a DNA-level selective regime and use high-resolution microarray data in yeast to compare the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 64 references

A high-resolution atlas of nucleosome occupancy in yeast

Nature Genetics • 2007
View 8 Excerpts
Highly Influenced

Statistical analysis of nucleosome formation sites

L Orlov Iu, VG Levitskii, OG Smirnova, OA Podkolodnaia, TM Khlebodarova
Biofizika • 2006
View 4 Excerpts
Highly Influenced

A high-resolution map of nucleosome positioning on a fission yeast centromere

JS Song, X Liu, XS Liu, X He
Genome Res • 2008
View 1 Excerpt

RNA landscape of evolution for optimal exon and intron discrimination.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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