The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast

  title={The Impact of the Nucleosome Code on Protein-Coding Sequence Evolution in Yeast},
  author={Tobias Warnecke and Nizar N. Batada and Laurence D. Hurst},
  journal={PLoS Genetics},
  pages={R75 - 633}
Coding sequence evolution was once thought to be the result of selection on optimal protein function alone. Selection can, however, also act at the RNA level, for example, to facilitate rapid translation or ensure correct splicing. Here, we ask whether the way DNA works also imposes constraints on coding sequence evolution. We identify nucleosome positioning as a likely candidate to set up such a DNA-level selective regime and use high-resolution microarray data in yeast to compare the… CONTINUE READING

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