The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.

@article{Deak1999TheIO,
  title={The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.},
  author={Terrence Deak and Kien T. Nguyen and Andrea L Ehrlich and Linda R. Watkins and Robert L Spencer and Steven F. Maier and Julio Licinio and M L Wong and George P. Chrousos and Elizabeth L. Webster and Philip W. Gold},
  journal={Endocrinology},
  year={1999},
  volume={140 1},
  pages={79-86}
}
The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it’s potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by a-helical CRH attenuates conditioned fear responses, we sought to test antalarmin in… CONTINUE READING