The Impact of Timing and Duration of Thiopurine Treatment on First Intestinal Resection in Crohn's Disease: National UK Population-Based Study 1989–2010

@article{Chatu2014TheIO,
  title={The Impact of Timing and Duration of Thiopurine Treatment on First Intestinal Resection in Crohn's Disease: National UK Population-Based Study 1989–2010},
  author={Sukhdev Chatu and Sonia Saxena and Venkataraman Subramanian and Vasa Curcin and Ghasem Yadegarfar and Laura Gunn and Azeem Majeed and Richard C Pollok},
  journal={The American Journal of Gastroenterology},
  year={2014},
  volume={109},
  pages={409-416}
}
  • Sukhdev Chatu, Sonia Saxena, +5 authors Richard C Pollok
  • Published in
    The American Journal of…
    2014
  • Medicine
  • OBJECTIVES:The efficacy of thiopurines (TPs) in altering the risk of surgery in Crohn's disease (CD) remains controversial. We evaluated the impact of TP therapy, optimal timing, and duration of TP therapy on first intestinal resection rates using a population-based cohort.METHODS:We constructed a population-based cohort of incident cases of CD between 1989 and 2005. We used the Kaplan–Meier analysis to calculate time trends in TP use and first intestinal resection in three groups defined by… CONTINUE READING

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