The Impact of Resveratrol on Oxidative Stress Induced by Methotrexate in Rat Ileum Tissue: Evaluation of Biochemical and Histopathological Features and Analysis of Gene Expression

@article{Ozcicek2015TheIO,
  title={The Impact of Resveratrol on Oxidative Stress Induced by Methotrexate in Rat Ileum Tissue: Evaluation of Biochemical and Histopathological Features and Analysis of Gene Expression},
  author={Adalet Ozcicek and Nihal Yurteri Çetin and Ferda Keskin Çimen and Levent Tumkaya and Ismail Malkoç and Mine Gulaboglu and Oğuzhan Yaralı and Bahadir Suleyman},
  journal={Medical Principles and Practice},
  year={2015},
  volume={25},
  pages={181 - 186}
}
Objective: The aim of this study was to assess the impact of resveratrol (RST) on oxidative stress induced by methotrexate in rat ileum tissue. Materials and Methods: Twenty-four rats were divided into 4 groups with 6 in each group. Each rat was orally administered the following every day for 30 days: group 1 (MTXG), methotrexate (MTX; 5 mg/kg); group 2 (RMTXG), MTX (5 mg/kg) plus RST (25 mg/kg/day); group 3 (RSTG), RST alone (25 mg/kg/day), and group 4 (controls), distilled water. After the… Expand
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References

SHOWING 1-10 OF 38 REFERENCES
The Protective Effect of Hesperidin on Methotrexate-Induced Intestinal Epithelial Damage in Rats: An Experimental Study
TLDR
HES seemed to have a protective effect against methotrexate-induced intestinal injury and the proliferation-enhancing effect of HES also appeared in healthy rats. Expand
Efficacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats.
  • L. Kaynar, A. Çetin, +8 authors S. Silici
  • Medicine
  • African journal of traditional, complementary, and alternative medicines : AJTCAM
  • 2012
TLDR
Although RJ addition had no effect on the decreased mucosal thickness and villus/crypt ratio in MTX groups, it caused an improvement in the antioxidant levels and a remarkable decrease in MDA levels. Expand
Effects of Resveratrol on Methotrexate-Induced Testicular Damage in Rats
TLDR
The results indicate that RES has protective effects against MTX-induced testis damage at the biochemical, histopathological, and apoptotic levels. Expand
Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress.
TLDR
Results suggest that turmeric extract may protect the small intestine of rats from methotrexate-induced damage and Turmeric effects could result from its antioxidant properties. Expand
Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents
TLDR
The results suggest an important role of nitric oxide, via activation of iNOS, in the pathogenesis of intestinal mucositis, as indicated by the reduced villus and crypt damages, inflammatory alterations, cell death, MPO activity, and nitrotyrosine immunostaining due to MTX challenge. Expand
Amelioration of methotrexate‐induced enteritis by melatonin in rats
TLDR
It is demonstrated that melatonin is capable of reversing MTX‐induced intestinal dysfunctions, indicating that it may be beneficial in ameliorating the symptoms of chemotherapy‐induced enteritis. Expand
Beta-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects.
TLDR
The findings of the present study suggest that beta-glucan, through its antioxidant and immunoregulatory effects, may be of therapeutic value in alleviating the leukocyte apoptosis, oxidative tissue injury and thereby the intestinal and hepatorenal side effects of methotrexate treatment. Expand
Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats
TLDR
Findings suggest that S. boulardii ameliorates intestinal injury and the accompanying hepatic inflammation by supporting the antioxidant state of the tissues and by inhibiting the recruitment of neutrophils. Expand
Beneficial effects of cathepsin inhibition to prevent chemotherapy‐induced intestinal mucositis
TLDR
A large broad inhibition ofCathepsin D activity, used as a marker of lysosomal pathway, was reduced both in E64 and pepstatin‐treated rats, however, villus atrophy and intestinal damage observed in methotrexate‐ treated rats were restored in Rats receiving E64 but not in rats receiving pepStatin A. Expand
Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.
TLDR
It is strongly suggested that enterobacterial translocation in the mucosa is the first step required for activation of various factors such as iNOS/NO and neutrophils, all involved in the pathogenesis of indomethacin-induced intestinal lesions. Expand
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