The Immunopathology of Multiple Sclerosis: An Overview

@article{Lassmann2007TheIO,
  title={The Immunopathology of Multiple Sclerosis: An Overview},
  author={H. Lassmann and W. Br{\"u}ck and Claudia F. Lucchinetti},
  journal={Brain Pathology},
  year={2007},
  volume={17}
}
Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease, characterized by the formation of focal demyelinated plaques in the white matter of the central nervous system. In this review we describe recent evidence that the spectrum of MS pathology is much broader. This includes demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter. The mechanisms responsible for the formation of focal lesions in… Expand
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