The Immunopathology of Multiple Sclerosis: An Overview

@article{Lassmann2007TheIO,
  title={The Immunopathology of Multiple Sclerosis: An Overview},
  author={Hans Lassmann and Wolfgang Br{\"u}ck and Claudia F. Lucchinetti},
  journal={Brain Pathology},
  year={2007},
  volume={17}
}
Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease, characterized by the formation of focal demyelinated plaques in the white matter of the central nervous system. In this review we describe recent evidence that the spectrum of MS pathology is much broader. This includes demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter. The mechanisms responsible for the formation of focal lesions in… 
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  • 2018
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TLDR
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TLDR
Histological, immunological and neuroimaging studies have provided new insight in this rapidly expanding field, and form the basis of the most recent hypotheses on the pathogenesis of grey matter damage.
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TLDR
Chronic active lesions are thought to increase in size over time and may represent a mechanism for worsening in progressive MS, and may have different genetic underpinnings in white and gray matter.
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Progressive multiple sclerosis
TLDR
It is shown that also in progressive MS, inflammation is the driving force for brain injury and that the discrepancy between inflammation-driven tissue injury and response to immunomodulatory therapies can be explained by different pathomechanisms acting in RRMS and progressive MS.
Inflammation in multiple sclerosis--sorting out the gray matter.
  • P. Calabresi
  • Medicine, Psychology
    The New England journal of medicine
  • 2011
TLDR
The findings of the study by Lucchinetti et al provide definitive evidence that inflammatory disease of the gray matter commences early in the pathogenesis of some cases of multiple sclerosis.
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TLDR
Findings of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include: a primary degenerative process, generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells.
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