The Immunobiology of Mushrooms

  title={The Immunobiology of Mushrooms},
  author={Andrea T. Borchers and Anita Krishnamurthy and Carl L Keen and Frederick J. Meyers and M. Eric Gershwin},
  journal={Experimental Biology and Medicine},
  pages={259 - 276}
There has been enormous interest in the biologic activity of mushrooms and innumerable claims have been made that mushrooms have beneficial effects on immune function with subsequent implications for inhibition of tumor growth. The majority of these observations are anecdotal and often lack standardization. However, there remains considerable data on both in vitro and in vivo effects that reflect on the potential of mushroom compounds to influence human immunity. A number of these effects are… 

Tables from this paper

Effectiveness of immunotherapies from oyster mushroom (Pleurotus species) in the management of immunocompromised patients

The immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

The immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

Immunostimulatory properties of a polysaccharide isolated from Astraeus hygrometricus.

The present study aims to explore the immunomodulatory properties of polysaccharide isolated from the mushroom Astraeus hygrometricus and finds that it enhanced natural killer cell activation and proliferation of splenocytes with an increase in the T-helper 1 cytokine level ofsplenocyte culture supernatant.

Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

The current status of clinical studies on immunomodulatory activities of mushrooms and mushroom products are reviewed and the approaches that have been used in the development and application of bioactive compounds extracted from mushrooms are described.

Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review

  • P. A. Ayeka
  • Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2018
Since time immemorial, plants and their compounds have been used in the treatment and management of various ailments. Currently, most of conventional drugs used for treatment of diseases are either

Potential role of mushroom beta-glucans in immunity and inflammation in viral infections and COVID-19

Understanding whether the TRIM processes are responsible for antiviral responses will undoubtedly provide a deeper understanding of other potential antiviral strategies, as the new SARS-CoV-2 is not the first- or last-time humanity has to deal with viral pandemics.

Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action

Information is compiled on the characteristics of medicinal mushrooms that appear to be particularly effective as biological immunotherapeutic agents in cancer treatment and the future prospects of using medicinal mushrooms as potent supportive candidate bioagents for treatment of cancers is discussed.

Antitumor properties of a heteroglucan isolated from Astraeus hygrometricus on Dalton's lymphoma bearing mouse.

Assessing the immunomodulatory potential of high-molecular-weight extracts from mushrooms; an assay based on THP-1 macrophages.

An assay was developed suitable to distinguish the immunomodulatory properties of food compounds in a reproducible manner using the human monocytic cell line THP-1, and it was determined that the assay performs best when using cells at a concentration of (2.5-5) × 10(5) cells mL(-1).



Mushrooms, Tumors, and Immunity: An Update

This review will present the comparative biology with respect to both immunological and antitumor activities of mushroom extracts and also highlight the need for further evidence-based research.

Mushrooms, tumors, and immunity.

The antitumor mechanisms of several species of whole mushrooms as well as of polysaccharides isolated from Lentinus edodes, Schizophyllum commune, Grifola frondosa, and Sclerotinia sclerotiorum are mediated largely by T cells and macrophages, and the means by which they modulate the immune system and potentially exert tumor-inhibitory effects are reviewed.

Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice.

Increased intake of white button mushrooms may promote innate immunity against tumors and viruses through the enhancement of a key component, NK activity, which might be mediated through increased IFNgamma and TNFalpha production.

Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley.

It is found that purified polysaccharides from GL mycelium could induce human PBMC proliferation and phenotypic and functional maturation of DCs with significant IL-12 and IL-10 production, and poly Saccharides of different sources have different immune potency and effect on human immune cells including DCs.

Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.

Maitake D-Fraction appears to repress cancer progression and primarily exerts its effect through stimulation of NK activity, and measurement of NK cell activity is concluded to be a useful clinical parameter in monitoring disease progression during and following immunotherapy with maitake LFraction.

Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice.

The results suggest that D-Fraction induced a Th-2 dominant response through the activation of macrophages, resulting in the enhancement of humoral immunity rather than cell-mediated immunity.

Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy.

Findings provide evidences that GL-M has immunomodulating effects on human immune cells and therefore can be used as a natural adjuvant for cancer immunotherapy with DCs.

Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells.

It is suggested that NK cells are not only responsible for the early effects of D-Fraction on tumor growth, but also for the long-term tumor-suppressive effects of C3H/HeN mice through increased IL-12 released from macrophages through increased macrophage-derived interleukin (IL)-12.

Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice.

  • Y. ChanTim Chang Ching Li
  • Biology, Medicine
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • 2007
It is concluded that A. blazei Murill possesses a wide range of immunomodulatory effects in vivo, and its extract was associated with significant enhancement of seven out of nine immune functions tested.

Stimulation of the natural immune system in normal mice by polysaccharide from maitake mushroom

Results indicate that D-Fraction stimulates the natural immunity related to the activation of NK cells indirectly through IL-12 produced by macrophages and dendritic cells, therefore, administration of D-fraction to healthy individuals may serve to prevent infection.