The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus.

@article{Merlo2002TheIK,
  title={The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus.},
  author={Emiliano Merlo and Ramiro A M Freudenthal and Arturo Romano},
  journal={Neuroscience},
  year={2002},
  volume={112 1},
  pages={161-72}
}
Evidence for the participation of Rel/NF-kappaB transcription factors in long-term memory has recently been reported in the context-signal learning paradigm of the crab Chasmagnathus, in which a high correlation between long-term memory formation and NF-kappaB activation was observed. Two components of the NF-kappaB pathway in the crab brain have now been identified by cross-immunoreactivity using mammalian antibodies for IkappaB-alpha and IkappaB kinase alpha. Furthermore, IkappaB kinase-like… CONTINUE READING

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