The IgG autoimmune response in postpartum acquired hemophilia A targets mainly the A1a1 domain of FVIII.

Abstract

BACKGROUND Acquired hemophilia A (AHA) is a severe life-threatening autoimmune disease due to the development of autoantibodies that neutralize the procoagulant activity of factor VIII (FVIII). In rare cases, AHA occurs in the postpartum period as a serious complication of an otherwise normal pregnancy and delivery. Due to its rarity, little is known about… (More)
DOI: 10.1111/j.1538-7836.2012.04850.x

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Cite this paper

@article{Lapalud2012TheIA, title={The IgG autoimmune response in postpartum acquired hemophilia A targets mainly the A1a1 domain of FVIII.}, author={Priscilla Lapalud and T. Ali and Christopher Cayzac and Eve Mathieu-Dupas and Hector Levesque and Christian Pfeiffer and Julien Balicchi and Yves Gruel and Joseph Borg and J. F. Schved and Catherine Granier and G{\'e}raldine Lavigne-Lissalde}, journal={Journal of thrombosis and haemostasis : JTH}, year={2012}, volume={10 9}, pages={1814-22} }