The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.

@article{Mittermann2008TheIA,
  title={The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.},
  author={Irene Mittermann and Renate Reininger and Maya Zimmermann and Katharina Gangl and Jürgen Reisinger and Karl J. Aichberger and Elli K. Greisenegger and Verena Niederberger and Joachim Seipelt and Barbara Bohle and Tamara Kopp and Cezmi A. Akdis and Susanne Spitzauer and Peter Valent and Rudolf Valenta},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 6},
  pages={
          1451-9
        }
}
Hom s 2, the alpha-chain of the nascent polypeptide-associated complex, is an intracellular autoantigen that has been identified with IgE autoantibodies from atopic dermatitis patients. We investigated the humoral and cellular immune response to purified recombinant Hom s 2 (rHom s 2). rHom s 2 exhibited IgE reactivity comparable to exogenous allergens, but did not induce relevant basophil cell degranulation. The latter may be attributed to the fact that patients recognized single epitopes on… 
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References

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TLDR
Hom s 4-induced IFN-γ production was found in normal individuals, in patients with chronic inflammatory skin diseases and in Th2-prone atopic persons, suggesting that Hom s 4 represents a protein with an intrinsic property to induce Th1-mediated autoreactivity.
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TLDR
To unravel the molecular nature of IgE-defined autoantigens, serum IgE from atopic dermatitis patients were used to screen a human epithelial cDNA expression library and an almost complete sequence identity with a recently described antigen recognized by cytotoxic T cells of a squamous cell carcinoma patient was exhibited.
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TLDR
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TLDR
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TLDR
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