The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.
@article{Mittermann2008TheIA, title={The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.}, author={Irene Mittermann and Renate Reininger and Maya Zimmermann and Katharina Gangl and Jürgen Reisinger and Karl J. Aichberger and Elli K. Greisenegger and Verena Niederberger and Joachim Seipelt and Barbara Bohle and Tamara Kopp and Cezmi A. Akdis and Susanne Spitzauer and Peter Valent and Rudolf Valenta}, journal={The Journal of investigative dermatology}, year={2008}, volume={128 6}, pages={ 1451-9 } }
Hom s 2, the alpha-chain of the nascent polypeptide-associated complex, is an intracellular autoantigen that has been identified with IgE autoantibodies from atopic dermatitis patients. We investigated the humoral and cellular immune response to purified recombinant Hom s 2 (rHom s 2). rHom s 2 exhibited IgE reactivity comparable to exogenous allergens, but did not induce relevant basophil cell degranulation. The latter may be attributed to the fact that patients recognized single epitopes on…
49 Citations
Cytokine effects induced by the human autoallergen α-NAC.
- Biology, MedicineThe Journal of investigative dermatology
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Insight is provided into the mechanisms of autoallergy, investigating the interplay of immune cells, signaling events, and cytokines, which are known to be relevant in atopic skin inflammation.
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- Biology, MedicineThe Journal of Immunology
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- Biology, MedicineAllergy, asthma & immunology research
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- Biology, MedicineThe Journal of allergy and clinical immunology
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- Biology, MedicineThe Journal of allergy and clinical immunology
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- Medicine, BiologyArchivum Immunologiae et Therapiae Experimentalis
- 2016
The pathogenesis of AD is evaluated and the emerging role of autoreactivity to various keratinocyte antigens involving both the humoral and cellular components of the immune system is evaluated.
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- Biology, MedicineExpert review of clinical immunology
- 2016
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