The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.

@article{Mittermann2008TheIA,
  title={The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma.},
  author={Irene Mittermann and Renate Reininger and Maya Zimmermann and Katharina Gangl and J{\"u}rgen Reisinger and Karl J. Aichberger and Elli K. Greisenegger and Verena Niederberger and Joachim Seipelt and Barbara Bohle and Tamara Kopp and Cezmi A Akdis and Susanne Spitzauer and Peter Valent and Rudolf Valenta},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 6},
  pages={
          1451-9
        }
}
Hom s 2, the alpha-chain of the nascent polypeptide-associated complex, is an intracellular autoantigen that has been identified with IgE autoantibodies from atopic dermatitis patients. We investigated the humoral and cellular immune response to purified recombinant Hom s 2 (rHom s 2). rHom s 2 exhibited IgE reactivity comparable to exogenous allergens, but did not induce relevant basophil cell degranulation. The latter may be attributed to the fact that patients recognized single epitopes on… CONTINUE READING

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