The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association.

@article{McDevit2005TheIK,
  title={The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association.},
  author={Daniel C. McDevit and Leslie Perkins and Michael L Atchison and Barbara S Nikolajczyk},
  journal={Journal of immunology},
  year={2005},
  volume={174 5},
  pages={2834-42}
}
The Igkappa locus is recombined following initiation of a signaling cascade during the early pre-B stage of B cell development. The Ig kappa3' enhancer plays an important role in normal B cell development by regulating kappa locus activation. Quantitative analyses of kappa3' enhancer chromatin structure by restriction endonuclease accessibility and protein association by chromatin immunoprecipitation in a developmental series of primary murine B cells and murine B cell lines demonstrate that… CONTINUE READING

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