The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

@article{Berardi1999TheIF,
  title={The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.},
  author={Marcelo J. Berardi and C Sun and Martin D Zehr and Frits Abildgaard and Jianhe Peng and Nancy A Speck and John H. Bushweller},
  journal={Structure},
  year={1999},
  volume={7 10},
  pages={1247-56}
}
BACKGROUND CBFA is the DNA-binding subunit of the transcription factor complex called core binding factor, or CBF. Knockout of the Cbfa2 gene in mice leads to embryonic lethality and a profound block in hematopoietic development. Chromosomal disruptions of the human CBFA gene are associated with a large percentage of human leukemias. RESULTS Utilizing nuclear magnetic resonance spectroscopy we have determined the three-dimensional fold of the CBFA Runt domain in its DNA-bound state, showing… CONTINUE READING