The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin.

Abstract

Titin is a gigantic elastic filament that determines sarcomere ultrastructure and stretch response in vertebrate muscle. It folds into numerous Ig and FnIII domains connected in tandem. Data on interdomain arrangements and dynamics are essential for understanding the function of this filament. Here, we report a mechanistic analysis of the conformational… (More)

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@article{Marino2006TheID, title={The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin.}, author={Marco Marino and Peijian Zou and Dmitri I. Svergun and Pilar Moreno Garc{\'i}a and Christian Edlich and Bernd Simon and Matthias Wilmanns and Claudia Muhle-Goll and Olga Mayans}, journal={Structure}, year={2006}, volume={14 9}, pages={1437-47} }