The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.

@article{Deuring2000TheIC,
  title={The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.},
  author={Renate Deuring and Laura Fanti and Jennifer A. Armstrong and M Sarte and Ophelia Papoulas and Matthias Prestel and Gary Daubresse and Margherita Verardo and Sarah L Moseley and Maria Berloco and Toshio Tsukiyama and Chao-Ting Wu and Sergio Pimpinelli and John W. Tamkun},
  journal={Molecular cell},
  year={2000},
  volume={5 2},
  pages={355-65}
}
Drosophila ISWI, a highly conserved member of the SWI2/SNF2 family of ATPases, is the catalytic subunit of three chromatin-remodeling complexes: NURF, CHRAC, and ACF. To clarify the biological functions of ISWI, we generated and characterized null and dominant-negative ISWI mutations. We found that ISWI mutations affect both cell viability and gene expression during Drosophila development. ISWI mutations also cause striking alterations in the structure of the male X chromosome. The ISWI protein… CONTINUE READING
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