The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.

@article{Durfee2010TheIC,
  title={The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.},
  author={Larissa A Durfee and Nancy A Lyon and Kyungwoon Seo and Jon M. Huibregtse},
  journal={Molecular cell},
  year={2010},
  volume={38 5},
  pages={722-32}
}
ISG15 is an interferon-induced and antiviral ubiquitin-like protein (Ubl). Herc5, the major E3 enzyme for ISG15, mediates the ISGylation of more than 300 proteins in interferon-stimulated cells. In addressing this broad substrate selectivity of Herc5, we found that: (1) the range of substrates extends even further and includes many exogenously expressed foreign proteins, (2) ISG15 conjugation is restricted to newly synthesized pools of proteins, and (3) Herc5 is physically associated with… CONTINUE READING
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expressed proteins functioning in diverse cellular pathways

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