The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.

@article{DeCosmo2013TheIG,
  title={The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry.},
  author={Salvatore De Cosmo and Sabrina Prudente and Olga Lamacchia and Laura Pucci and Daniela Lucchesi and Christine Mendonca and Diego Bailetti and Massimiliano Copetti and Fabio Pellegrini and Mauro Cignarelli and Giuseppe Penno and Alessandro Doria and Vincenzo Trischitta},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2013},
  volume={28 12},
  pages={
          3031-4
        }
}
  • S. De Cosmo, S. Prudente, +10 authors V. Trischitta
  • Published 2013
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND In Mexican Americans, the IRS1 G972R polymorphism (rs1801278) has been associated to such a marked reduction in glomerular filtration rate (GFR) (i.e. β = -8.3 mL/min/1.73 m(2)) to be considered a major determinant of kidney function. METHODS This was a cross-sectional study to investigate whether a similarly strong effect can also be observed among individuals of European ancestry. We investigated a total of 3973 White patients with type 2 diabetes. Standardized serum creatinine… Expand
The rs12917707 polymorphism at the UMOD locus and glomerular filtration rate in individuals with type 2 diabetes: evidence of heterogeneity across two different European populations
  • S. Prudente, R. Di Paola, +11 authors V. Trischitta
  • Biology, Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2017
TLDR
The previously reported strong association between rs12917707 and GFR in diabetic patients from Sweden is not observed in Italian diabetic patients, thus clearly pointing to a heterogeneous effect across the two different samples, suggesting that UMOD is a strong genetic determinant of kidney function in patients with T2D in some, but not all, populations. Expand
Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes
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This study, so far the largest addressing the relationship between serum adiponectin and GFR in T2D, strongly suggests that the paradoxical inverse association, previously reported in different clinical sets, is also observed in diabetic patients. Expand
Insulin receptor gene polymorphisms modify the progression of kidney failure in diabetic nephropathy patients
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The results support the hypothesis of insulin resistance and glucose intolerance contribute to CKD and suggest that the INSR gene polymorphisms modify the progression of kidney failure in diabetic nephropathy patients. Expand

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  • S. De Cosmo, S. Prudente, +12 authors V. Trischitta
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
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TLDR
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The objective of this study is to identify and characterize the genetic variants related to the glomerular filtration rate (GFR) linkage on 2q37. Of the positional candidate genes, we selectedExpand
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Insulin resistance and the cluster of abnormalities related to the metabolic syndrome are associated with reduced glomerular filtration rate in patients with type 2 diabetes.
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The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.
TLDR
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